Bloinformatics

• Locate within the Protein Data Bank the 3-D structure of an aspartic proteinase enzyme. State what your chosen entry is, and download the coordinates for the structure to use with Rasmol to investigate your chosen structure.
• Identify, using an appropriate bioinformatics program, the active site residues for your chosen PDB entry. Show the output generated by the program used.
• Using the program rasmol or Swiss-PDB Viewer produce an image of the structure that you think clearly illustrates the major structural features within the enzyme and clearly shows the location of the active site residues. State the commands used within the selected program to obtain your image.
• Discuss which types of bioinformatics tools that could be used to design inhibitors for aspartic proteinase.