Cause sof nephrotic syndrome and it can lead to kidney failure
Focal segemntal glmuerosclerosis is a one of the cause sof nephrotic syndrome and it can lead to kidney failure
requiring dialysis. knowing whether it is primary or secondary is clinically important as primary FSGS is likely
to recur post transplantation.
I would like you kindney mention prevelance of FSGS then percentage of patients with FSGS needed trasnplant
( primary and secodnary ), then percent of patient with primary and secondary FSGS had recurrence post
trassplantation. and mean/median at recurrance.
Sample Solution
Prevalence:
- FSGS is a common cause of nephrotic syndrome, particularly in adults.
- The exact prevalence varies depending on the population studied, but it is estimated to be around 10-20% of cases of nephrotic syndrome.
Percentage of Patients Requiring Transplantation:
- A significant proportion of patients with FSGS will eventually progress to end-stage kidney disease (ESKD) and require transplantation.
- Studies have shown that approximately 30-40% of patients with FSGS will require a kidney transplant.
Full Answer Section
Primary vs. Secondary FSGS:- Primary FSGS: This is the most common type, with no identifiable underlying cause. It has a higher risk of recurrence after transplantation.
- Secondary FSGS: This is caused by an underlying condition, such as HIV infection, hypertension, or drug use. It has a lower risk of recurrence after transplantation.
- The recurrence rate of FSGS after transplantation is significantly higher for primary FSGS compared to secondary FSGS.
- Studies have reported recurrence rates for primary FSGS ranging from 30-80%, while recurrence rates for secondary FSGS are typically lower.
- The risk of recurrence can also vary depending on other factors, such as the patient's age, the type of donor kidney, and the use of immunosuppressive medications.
- The mean and median time to recurrence of FSGS after transplantation can vary widely, but it is typically within the first few years following transplantation.
- Some studies have reported a median recurrence time of around 1-2 years.