DNA replication, repair and recombination

a) How long would it take in minutes to replicate the E. coli chromosome if it used unidirectional rather than bidirectional replication? Explain how you calculated this answer.

b) Not accounting for individual chromosomes and telomeres, i.e., use genome size, polymerization rate, and number of origins, how long should it take in hours to replicate the diploid human genome? Explain how you calculated this answer. Why is this calculated time less than the observed time?

Q10.2: Describe the structure and function of miRNA, snRNA, and lncRNA, which represent the three major types of noncoding RNAs; what are four mechanisms by which lncRNA molecules are thought to regulate cellular processes?