Describe a pharmaceutical you make up in detail. Use this list and describe each aspect of this fantasy pharmaceutical. This assignment is written as a list of each of the topics covered in the list. Full written sentences are expected for each topic below on the list except for the Drug Name and the Drug Structure. Cite all references. References are expected for every item on the list.
Drug Names [trade name(s), generic name(s)] - describe all the drug names 4 points be creative! For example, last year there was a drug called BYBYBILLY (pronounced bye-bye billy) that targeted jaundice in newborns
Drug Formulation [pill, infusion, etc] and REASON(S) for this formulation 5 points
Drug Target. What is it? What does it do in the cell? How is it regulated? This is a standard description of how a protein, molecule, gene, etc works in a cell and how the cell, body, etc regulates it. 15 points
Purpose of Targeting that Protein, Gene, Molecule, etc. Why would you want to target that molecule? 15 points
Drug Mechanism(s) of Action [at all levels molecular, cellular, organ, organ system, etc]-what does it bind to, how does it work, what does it do, what type of inhibitor is it (if it’s an inhibitor), how does it bind/binding plots, what genes does it regulate, be absolutely thorough, and CREATIVE. 25 points
Drug Distribution Throughout the Body - where does it go and why would you want it to go there. Here's where if you attached your drug to something to target it there, you'd want to write about it. Don't forget about the BBB, if you need to get it into the brain. 5 points
Drug Elimination (renal, hepatic, fecal, etc) and why. Here's where you describe it if are lipophilic or hydrophilic and how that effects. You might also want those described in Distribution as well if you need the drug to go somewhere. - 5 points
Off-Target Effects - 5 points
Reason(s) for Off-Target Effects. This should be in detail about why these off-target effects are seen. For example for condensin, that's in all cells so I'd get far-reaching toxic effects and I'd need to describe what would happen if condensin is inactivated in all cells. 14 points
References are complete 2 points