For any 3 of the following drugs, compare the pharmacokinetics of the sustained release and
immediate release formulations available on the market. Suggest how doses of the sustained
release and the intermediate release products can be interchanged along with their dosing intervals. Explain the impact on the steady state Cmax and Cmin as well as on the pharmacologic effect if a patient misses one dose of either formulation. Provide evidence from pharmacokinetic studies.
• Zolpidem
• Bupropion
• Verapamil
• Nifedipine
• Oxybutynin
• Metformin