How UVA and UVB rays contribute to the process of oncogenesis in skin cells
Leonard works in the agriculture industry and raises beef cattle. At 60 years of age, he has spent most of his life working outdoors harvesting hay and tending to his herds. His wife was the first to notice a change in his skin. One day, after taking off his shirt, she noticed a significant change in the mole he had on his right shoulder. It not only was darker but was moist and appeared to have been bleeding at one point. Surrounding the mole, his skin was red. His wife remembered hearing stories of Leonard working on his father’s farm, spending long hours out in the hot sun even though his father had gone into the barn to work during the hottest part of the day. She insisted him go to the family physician to have it examined (Chapter 52, Learning Objectives 10 and 11).
Leonard’s physician performed a biopsy on the lesion and told Leonard he suspected the growth may be malignant melanoma. What cells are affected in this form of skin cancer? How might his childhood exposures to the sun predispose him to this form of cancer?
How do UVA and UVB rays contribute to the process of oncogenesis in skin cells?
The mole on Leonard’s shoulder was a nevocellular nevus. What are the cellular composition and appearance of this type of mole before it underwent malignant change?
Sample Solution
Malignant melanoma is a type of skin cancer that develops from melanocytes, the cells that produce melanin, the pigment that gives skin its color. Melanoma is the most serious type of skin cancer, and it can be fatal if it is not detected and treated early.
Full Answer Section
UV radiation from the sun can be divided into two types: UVA and UVB rays. UVA rays penetrate the skin more deeply than UVB rays, and they are more likely to cause premature aging of the skin. UVB rays are more likely to cause sunburn, but they are also more likely to cause skin cancer.
Nevocellular Nevus
The mole on Leonard's shoulder was a nevocellular nevus, also known as a common mole. Nevocellular nevi are benign growths that are made up of melanocytes. They are the most common type of mole, and they are usually harmless. However, some nevocellular nevi can become malignant melanoma.
The cellular composition of a nevocellular nevus is similar to the cellular composition of normal skin. The mole is made up of melanocytes, keratinocytes, and fibroblasts. Melanocytes are the cells that produce melanin, the pigment that gives skin its color. Keratinocytes are the cells that make up the outer layer of skin. Fibroblasts are the cells that produce collagen, the protein that gives skin its strength and elasticity.
The appearance of a nevocellular nevus can vary. Some moles are small and flat, while others are large and raised. Some moles are uniform in color, while others have different shades of brown or black. Some moles have a smooth surface, while others have a rough or bumpy surface.
Therapy for Malignant Melanoma
The treatment for malignant melanoma depends on the stage of the cancer. Early-stage melanoma can often be treated with surgery to remove the tumor. In some cases, radiation therapy or chemotherapy may also be used. Advanced-stage melanoma may require more aggressive treatment, such as immunotherapy or targeted therapy.
Conclusion
Leonard's case is a reminder of the importance of sun protection. Everyone should take steps to protect their skin from the sun, especially people who are at increased risk of developing skin cancer. These steps include wearing sunscreen, protective clothing, and sunglasses. They should also avoid tanning beds.
If you notice any changes in your skin, such as a new mole or a change in the appearance of an existing mole, it is important to see a doctor right away. Early detection and treatment of skin cancer is essential for a good outcome.
We are here to help
We have crazy offers
It’s quick and easy to place an order. We have an efficient customer service that works 24/7 to assist you.It’s quick and easy to place an order. We have an efficient customer service that works 24/7 to assist you.