Write a short review about the research status of a particular human disease in which protein aggregation and amyloid formation is an early and important event. Page limit: Five pages The review should cover the following:
1) Current knowledge of the disease and the impact to the society
2) Chemical, physical or other methods used for clinical diagnosis
3) How protein aggregates involved in the pathogenesis of the disease
4) The knowledge of the protein
5) Methods used in studying the protein aggregation for this disease
6) The chemical and physical understanding of the disease and the protein aggregation process
7) How various cells and subcellular components involved in making and removing the aggregates
8) Drug development by various pharmaceutical companies to tackle this disease
9) Future work or what need to be understood or the missing knowledge in the area of pathogenesis, diagnosis, and treatment