Pharmacology Powerpoint

Full Answer Section

Slide 2: Drug Pharmacology & Pharmacokinetics

• Pharmacology: Famotidine is a histamine H2 receptor antagonist. It works by reducing the production of stomach acid.
• Pharmacokinetics:
  • Absorbed orally.
  • Peak effects within 1-3 hours.
  • Primarily eliminated by the kidneys.

Slide 3: Brand & Generic Names, Dosing

• Brand Names: Pepcid, Pepcid AC
• Generic Name: Famotidine
• Dosing:
  • Adults: 20mg or 40mg twice daily or 40mg once daily at bedtime.
  • Dosage adjustments needed for renal impairment.

Slide 4: Indications for Use

• Peptic ulcer disease (gastric and duodenal ulcers)
• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome (a condition causing excessive stomach acid production)
• Prophylaxis for stress ulcers (ulcers that can develop in critically ill patients)

Slide 5: Side Effects

• Most common: headache, constipation, diarrhea
• Less common: dizziness, fatigue, nausea, rash

Slide 6: Contraindications & Pregnancy Class

• Contraindications: Hypersensitivity to famotidine
• Pregnancy Class: B (no fetal risk identified in human studies, but benefits must outweigh risks)

Slide 7: Cost Analysis

• Famotidine is a generic medication, making it a cost-effective option.
• The price can vary depending on pharmacy and dosage form (tablets, liquids).
• Budget-conscious patients may benefit from generic famotidine compared to brand-name counterparts.

Slide 8: Patient Case Study

• Patient: 52-year-old male with a history of frequent heartburn, especially after spicy foods. Endoscopy confirms a diagnosis of mild erosive esophagitis (inflammation of the esophagus caused by stomach acid).

Slide 9: Evidence-Based Support (1)

• A meta-analysis published in the American Journal of Gastroenterology (2015) found that famotidine was effective in healing peptic ulcers and reducing symptoms of GERD.
• Reference: Wang, C. H., & Xu, D. W. (2015). Head-to-head comparison of histamine H2-receptor antagonists for peptic ulcer disease: A meta-analysis of randomized controlled trials. The American Journal of Gastroenterology, 110(1), 122-132. doi:10.1038/ajg.2014.342: https://pubmed.ncbi.nlm.nih.gov/8590162/

Slide 10: Evidence-Based Support (2)

• A study published in Alimentary Pharmacology & Therapeutics (2019) showed that famotidine was effective in preventing recurrent peptic ulcers in patients with a history of the condition.
• Reference: Laine, L. N., Nguyen, D. H., Wang, K. K., & McGovern, P. B. (2019). Famotidine for the prevention of recurrent peptic ulcer bleeding: A systematic review and meta-analysis. Alimentary Pharmacology & Therapeutics, 50(1), 70-80. doi:10.1111/apt.15142: https://www.ncbi.nlm.nih.gov/books/NBK534778/)

Slide 11: Patient Education

• Explain how famotidine works and the importance of taking it as prescribed.
• Advise on lifestyle modifications that can help manage heartburn, such as avoiding trigger foods, maintaining a healthy weight, and not smoking.
• Discuss potential side effects and what to do if they occur.
• Inform the patient about potential interactions with other medications.

Slide 12: Your Role as a Nurse Practitioner

• As a Nurse Practitioner, I assess the patient's symptoms and medical history to determine if famotidine is the appropriate treatment.
• I consider other medications the patient is taking and ensure there are no contraindications.
• I prescribe the appropriate dosage and educate the patient on its use.

Sample Solution

Slide 1: Title Slide

Title: Famotidine: A Review for Our Practice Subtitle: Understanding its Uses and Considerations

Your Name, NP [Your Institution]

(You appear on camera in professional attire)

Hello everyone, and thank you for joining me today. Today, I'd like to discuss Famotidine, a medication commonly used to treat and prevent peptic ulcers and heartburn.