Presentation on Nephroblastoma in pediatrics

Develop a PowerPoint presentation on Nephroblastoma in pediatrics
1. Provide information about the incidence, prevalence, and pathophysiology of the disease/disorder to the cellular level.
o Differential Diagnosis
2. Educate advanced practice nurses on
o assessment and diagnostic exams (Remember, APRNs are the primary care providers)
o care/treatment, including genetics/genomics—specific for this disorder
3. Provide patient education for management, cultural, and spiritual considerations for care must also be addressed.
4. The PowerPoint Presentation needs to have BOTH video and voice-over to receive full credit for this assignment.
Submission Instructions:
• Followed the current APA format for PowerPoint slides, including citation of references.
• PowerPoint presentation with 10-15 slides, clear and easy to read. Speaker notes expanded upon and clarified the content on the slides.
• Incorporate a minimum of 4 current (published within the last five years) scholarly journal articles or primary legal sources (statutes, court opinions) within your work. Journal articles and books should be referenced according to the current APA style (the library has a copy of the APA Manual).

lide 12: Summary and Conclusion

Slide Title	Key Takeaways for the APRN
Content	Nephroblastoma is a curable pediatric cancer, requiring high clinical suspicion in preschool-age children with an abdominal mass. APRNS must perform a focused assessment, rapidly triage for imaging (US/CT), and counsel families on the multimodal treatment plan. Genomic testing (e.g., LOH 1p/16q) is critical for risk stratification and determining treatment intensity. Holistic care demands attention to long-term follow-up and respectful integration of the family's cultural and spiritual values.
Voice-Over/Video Note	Reiterate the high cure rate and the specific, crucial roles the APRN plays in the continuum of care—from primary diagnosis to survivorship.

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Slide 13: References

Slide Title	References (APA 7th Edition)
Content	List all 4+ current scholarly references (including the 4 required, published 2021–2025) and any other sources used in the presentation, formatted per APA 7th edition guidelines.

Sample Answer

Slide 4: Pathophysiology: Cellular and Genomic Basis

Slide Title	The Cellular Origin: Nephrogenic Rests & Genetics
Content	Origin: Thought to arise from nephrogenic rests (persistent embryonic renal tissue) within the kidney. Triphasic Histology: Classically composed of three cell types: blastemal, stromal, and epithelial. Genomic Factors: Key genes involved are WT1 and CTNNB1. WT1 (Wilms Tumor 1 Gene): Tumor suppressor gene on chromosome 11p13. Loss of function or mutation is common, often linked to genitourinary anomalies. CTNNB1 (Beta-catenin): Involved in the WNT signaling pathway. Mutations are typically associated with favorable histology.
Citation	Citation 2: Scholarly Article on WT1 or CTNNB1 mutations/pathophysiology (2021–2025)
Voice-Over/Video Note	Explain that the WT1 gene is the most well-known and why it links to certain congenital syndromes. This is crucial for family history/screening.

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Slide 5: Related Syndromes and Differential Diagnosis

Slide Title	Differential Diagnosis & Associated Syndromes
Content	Associated Syndromes (High Risk): WAGR Syndrome: Wilms Tumor, Aniridia, Genitourinary anomalies, Range of developmental delays (due to contiguous gene deletion, including WT1). Denys-Drash Syndrome: WT1 germline mutation; associated with nephropathy and male pseudohermaphroditism. Beckwith-Wiedemann Syndrome (BWS): IGF2 gene overexpression; associated with hemihypertrophy, organomegaly, and increased cancer risk. Differential Diagnosis: Neuroblastoma: Can mimic Wilms tumor, but typically crosses the midline and may present with elevated catecholamines. Renal Cell Carcinoma (Rare in Peds): Clear Cell Sarcoma of the Kidney (CCSK): Tends to metastasize to bone.
Voice-Over/Video Note	Emphasize the clinical importance of screening patients with these syndromes (e.g., routine abdominal ultrasounds for BWS patients).

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