Discuss the research study, and identify possible ethical issues within the research. Focus on the ethical principles learned this week. Consider possible issues in the research process; sampling, methodology, data collection, etc. The focus is on the research study, not the health issue. Explain how the ethical concerns can influence the research outcomes. Define validity as it relates to the research study; review previous learning activities for key validity concepts, to include internal and external validity, and associated threats to validity. Discuss importance of research design validity and how research bias can impact validity. (Hint: research design validity and instrumentation validity are different concepts). Discuss how stakeholders can externally influences health care research. Include possible ethical concerns. Summarize how not adhering to ethical guidelines could lead to outcome bias, and how limitations could influence research.