The Biology of canonical TGF-Beta Signalling in Squamous Cell Carcinomas

The Biology of canonical TGF-Beta Signalling in Squamous Cell Carcinomas

Order Description

The Biology of canonical TGF-Beta Signalling in Squamous Cell Carcinomas

Detailed background of TGF-Beta Signalling – its mechanism and importance including: Ligands (TGFB1, TGFB2 and TGFB3), Receptors (TGFBR1 and TGFBR2) and Smads (SMAD2, SMAD3 and SMAD4)

– Mechanism of how it acts as a tumour suppressor
– Mechanisms of how it acts as a tumour promoter
– (diagrams can be used to add

What role TGF-Beta signalling plays in Squamous Cell Carcinomas (SCC)
– Briefly explain what causes Squamous Cell Carcinomas
– Then focus on 4 types of SCC into separate section:
– 1. Cutaneous Squamous Cell Carcinoma (CSCC)
– 2. Head and Neck Squamous Cell Carcinoma (HNSCC)
– 3. Esophageal Squamous Cell Carcinoma (ESCC)
– Lung Squamous Cell Carcinoma (LSCC)

For each of the cancer type show the role of TGF-Beta, relating to
– Different prognosis rates (statistics)
– Mutational genetic frequencies of the core of signalling components
– Changes in gene expressions of the core of signalling components
– Loss of function and gain of function
– Overall survival rates
– Is it related to different perturbations in TGF-Bet signalling

Comparison
– If they are similar or different across the different squamous cancer types
– Is there any difference in spectrum of mutations and gene expression changes in in squamous cancers

Overall question – are there any dysregulation of TGF-Beta signalling in SCC
– Yes or No and then does that relate to any outcomes and are there quantitive or qualitive difference in the way that those changes take place are they similar or different across the four SCC types