The neurobiological of major depressive disorder

  do you have a 26 year old patient with MDD, you will initiate the patient on sertraline 25 mg PO daily. 1- What are the parameters or considerations for diagnosing MDD? 2- Describe the neurobiological of major depressive disorder (MDD). Include genetics, neurotransmitters, neuroanatomical changes, current theories of the cause of the disease, and cultural factors if it's involved.) 3- There is any medical condition that can mimic MDD? 4- What laboratories do you need to monitor? 5- what is the first line of treatment for (MDD). what is the neurochemistry action of sertraline, (SSRI), side effects to monitor, expected benefits for the patient, and contraindications?