Thinking of ourselves as made out of two different substances, Decartes

Should we, as human beings, think of ourselves as made out of two different substances, like Decartes argued? Or are you persuaded by the arguments of physicalism that we are purely physical beings?

If you agree with Descartes, how would you explain the fact that our mental life seems to be very closely connected to a physical organ, namely the brain. If you agree with physicalism, how do you explain the fact that our mental life seems to be like nothing else in the physical world (think of how unique something like consciousness is, for example).

Write your thoughts on these issues.